NKX 2 - 5 ( NK 2 transcription factor related , locus 5 ( Drosophila )
نویسندگان
چکیده
Protein Description 324 amino acids; 35-38 kDa, depending on phosphorylation status; contains one TN domain (residues 10-21), one homeodomain (residues 138197), and one NK2 domain (residues 212-234). Expression Expression is mainly restricted to the heart. But during embryogenesis NKX2-5 expression has also been detected in spleen-precursor cells. Localisation Cytoplasmatic and nuclear, probably depending on phosphorylation status.
منابع مشابه
Chick NKx-2.3 represents a novel family member of vertebrate homologues to the Drosophila homeo☐ gene tinman: differential expression of cNKx-2.3 and cNKx-2.5 during heart and gut development
NKx homeodomain proteins are members of a growing family of vertebrate transcription factors with strong homology to the NK genes in Drosophila. Here, we describe the cloning of cNKx-2.3 and cNKx-2.5 cDNAs and their expression during chick development. Both genes are expressed in the developing heart with distinct but overlapping spatio-temporal patterns. While cNKx-2.5 is activated in early pr...
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Homeobox genes have been implicated in a number of regulatory processes associated with the embryonic patterning and cell differentiation of eukaryotes (McGinnis and Krumlauf, 1992). The homeobox is a 180 bp DNA sequence which encodes a 60 amino acid protein motif, the homeodomain, that has been shown to serve as the DNA binding site for a phyletically and functionally diverse class of transcri...
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متن کاملIdentification and analysis of vnd/NK-2 homeodomain binding sites in genomic DNA.
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